The Search For Less Addictive Painkillers

Opioids work wonders for pain. However, as their addictive effects increase, their effectiveness decreases. The US is amid an epidemic right now, with about 2 million Americans addicted to opioid painkillers. So, doctors and researchers are searching for new ways to relieve pain with no addictive side effects. New research of opioids’ cellular workings offers a promising road to better pain relief without the addiction.

MDAN

One cell receptor is stimulated and the other is blocked. This is how you can get amazing pain relief without dependency. A team of chemists focused on the mu and delta receptors. Previous research has shown drugs that link up with mu receptors last longer with less addiction when combined with drugs that blocked delta receptors — called MDAN (Mu Delta agonist antagonist.) However, it’s unknown whether the two channels worked separately or together to improve the overall effect.

Superior Pain Blocking

The MDAN drug is around 50 times more effective in blocking pain than morphineMDAN still can’t compare to drugs designed purely to stimulate the mu receptor, which show over 100 times the pain blocking potential of morphine.

“Mice given morphine and then abruptly cleared of it showed severe agitation, jumping roughly 100 times in a 10 minute span, and mice given just the mu agonist showed similar agitation, jumping between 83 and 29 times over the same span, depending on the formulation. The mice given MDAN showed hardly any agitation at all, averaging less than one jump” (Proceedings of the National Academy of Sciences.) MDAN does not create an addictive dependency and the pain relief was constant through the entire experiment.

There is still a long road ahead until this kind of pain reliever is human trialed and mass-marketed, but that doesn’t mean it’s so far off. We could see results in as little as five to 10 years.

If you are experiencing pain, don’t wait any longer. Drop by your local ARCpoint Labs today or schedule an appointment for your wellness test.

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